Germline mutations are mutations that occur in every cell in your body and have the possibility to be passed down to your children. Germline variants in BRCA1 or BRCA2 are inherited in an autosomal dominant manner. The offspring of an individual identified as having a BRCA1 or BRCA2 germline pathogenic variant have a 50% chance of inheriting the variant from that parent.
Testing for Inherited cancer syndromes informs clinical decision making and may assist in the prevention of adverse health outcomes. BRCA1 and BRCA2 are part of complexes involved in DNA repair using homologous recombination.
Women with an abnormal BRCA1 or BRCA2 gene have up to an 80% risk of developing breast cancer by age 90 and up to 55% risk of developing ovarian cancer. In addition to breast cancer, mutations in the BRCA1/2 gene also increase the risk of ovarian, Fallopian tube, pancreatic cancer, gastric cancer and prostate cancers.
If there is a family history of breast cancer, other members of your family can undergo genomics testing to see if they are a carrier of germline BRCA mutations. If they are identified as a carrier of the mutations, this can enable them to:
If you are ready to proceed with testing, a Testing Request Form can be downloaded from our website. We recommend you book an appointment with your doctor to discuss the testing and have your Request Form signed. Once we receive your completed testing form and payment, Paternity For Life will send a testing kit directly to your home address. All that is required for testing is a simple, painless mouth swab. Once we receive your sample we will begin testing. Results are typically available to your doctor within 14 – 21 working days.